There is evidence from as early as 2500 B.C. that ancient Egyptians used cold to treat diseases and other ailments. The modern-day cryotherapy chamber was first conceived in Japan in 1978 by Dr. Toshima Yamaguchi, as a treatment for his patients suffering from rheumatoid arthritis. Since that time, the chamber has been further developed and refined in Europe, and now wide-spread whole-body cryotherapy is popular all over the world.

Multiple research studies have been published in medical journals about the effects of whole-body cryotherapy, and in many European countries the treatments are covered by medical insurance policies.

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Researchers are continuing to actively study the impact of cryotherapy in many areas.